Sentence examples for exaggerated accumulation of from inspiring English sources

This remodeling includes the exaggerated accumulation of ECM components in the interstitial and alveolar spaces and the disruption of the basement membranes.

Severe hypertension in ACE2-deficient mice was associated with exaggerated accumulation of Ang II in the kidney, as determined by MALDI-TOF mass spectrometry.

It is characterized by an exaggerated accumulation of fibrous collagens, by an increased incidence of interstitial cells in the renal interstitium and by the emergence of myofibroblasts.

IR affects the ability of the endoplasmic reticulum to synthesize and fold proteins, leading to the exaggerated accumulation of unfolded proteins and the initiation of ERS.

Steatotic livers present an exaggerated accumulation of lipids which contributes to the activation of various cellular stress signaling pathways and finally to increased vulnerability against IRI [ 3].

The persistent kidney injury induces renal inflammation, the overexpression of profibrotic factors and myofibroblast proliferation, followed by an exaggerated accumulation of extracellular matrix (ECM) components, destruction of the renal vasculature and ultimately renal fibrosis (Hewitson, 2009).

It is generally accepted that activated mesenchymal cells or myofibroblasts play a crucial role in the pathogenesis of various fibrotic diseases including interstitial pulmonary fibrosis, systemic sclerosis and liver or cardiac fibrosis being responsible for the exaggerated production and accumulation of extracellular matrix proteins in various organs affected by these diseases [ 1- 4].

Reviewing a large body of evidence on many chronic inflammatory diseases and carcinogenesis the author proposes that cancer is a severe form of hypersensitivity responses (immune disorder) in site-specific tissues resulting from accumulation of exaggerated expression and co-expression of immune responses and creation of a molecular immune tsunami, primarily in the immune-responsive tissues.

Organ fibrosis, the result of exaggerated, persistent, and often irreversible accumulation of extracellular matrix, complicates numerous diseases in all organs and tissues and has particularly serious consequences in the lungs.

We demonstrate that sleep loss, but not sleep fragmentation, in healthy mice increases sensitivity to noxious stimuli (referred to as 'pain') without general sensory hyper-responsiveness. Moderate daily repeated sleep loss leads to a progressive accumulation of sleep debt and also to exaggerated pain responses, both of which are rescued after restoration of normal sleep.

As compared to normal pregnancy, MO is associated with an exaggerated lipid mobilization (increased plasma cholesterol and triacylglycerol) and abnormal accumulation of fat in the liver, pancreas, and placenta [ 40, 131].