Sentence examples for exaggerated accumulation from inspiring English sources

This remodeling includes the exaggerated accumulation of ECM components in the interstitial and alveolar spaces and the disruption of the basement membranes.

It is characterized by an exaggerated accumulation of fibrous collagens, by an increased incidence of interstitial cells in the renal interstitium and by the emergence of myofibroblasts.

IR affects the ability of the endoplasmic reticulum to synthesize and fold proteins, leading to the exaggerated accumulation of unfolded proteins and the initiation of ERS.

Steatotic livers present an exaggerated accumulation of lipids which contributes to the activation of various cellular stress signaling pathways and finally to increased vulnerability against IRI [ 3].

The persistent kidney injury induces renal inflammation, the overexpression of profibrotic factors and myofibroblast proliferation, followed by an exaggerated accumulation of extracellular matrix (ECM) components, destruction of the renal vasculature and ultimately renal fibrosis (Hewitson, 2009).

Idiopathic pulmonary fibrosis (IPF) is a progressive and usually lethal disease of unknown etiology characterized by alveolar epithelial cell activation, fibroblast/myofibroblasts proliferation and activation and exaggerated accumulation of extracellular matrix (ECM) in lung parenchyma [ 1].

The exaggerated lipid accumulation in sucrose-palmitate-fed mice was attributable to a disproportionate rise in hepatic de novo lipogenesis.

It is generally accepted that activated mesenchymal cells or myofibroblasts play a crucial role in the pathogenesis of various fibrotic diseases including interstitial pulmonary fibrosis, systemic sclerosis and liver or cardiac fibrosis being responsible for the exaggerated production and accumulation of extracellular matrix proteins in various organs affected by these diseases [ 1- 4].

Reviewing a large body of evidence on many chronic inflammatory diseases and carcinogenesis the author proposes that cancer is a severe form of hypersensitivity responses (immune disorder) in site-specific tissues resulting from accumulation of exaggerated expression and co-expression of immune responses and creation of a molecular immune tsunami, primarily in the immune-responsive tissues.

This supports an impact of WASP accumulation on exaggerated IS stability once the coronin-1A function is impaired.

Organ fibrosis, the result of exaggerated, persistent, and often irreversible accumulation of extracellular matrix, complicates numerous diseases in all organs and tissues and has particularly serious consequences in the lungs.