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Boundary points are equidistant to exactly two sites, and vertices are equidistant to at least 3. Neighboring points are points whose associated Voronoi regions share a common boundary.
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For the real datasets, we used two reference targets genes of LexA, two of TyrR, two of URS1H and two of RAP1 each containing exactly one motif site for their respective regulators and we added to each of these individual genes their orthologs resulting in 8 datasets in total.
The results, visualized in Figure 4B, demonstrate that sites binding exactly two proteins were more enriched within 50 kb of breakpoints than sites binding exactly one in the genophilic cancers: Breast-Inaki (p = 2.3⋅10-5), Breast-Stephens (p = 0.0021), Breast-NikZainal (p = 0.22), Ovarian-McBride (p = 0.022) and Colorectal-Bass (p = 0.05).
We used only calls with genotypic phred scores ≥20 at sites with exactly two alternative types.
Of these true positives, in 6,287 of the E. coli intergenic regions two sites were predicted and the sites exactly coincided with the two planted sites.
The groups from the two sites were investigated with almost, but not exactly, the same protocol.
In 24 E. coli intergenic regions two sites were predicted and one of the two sites exactly coincided with a planted site.
Clearly disconnecting is exactly two components: (336).
Each column has exactly two nonzero entries.
Suppose you had exactly two beers.
The two sites' argument?
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