Because GRIMM requires that the compared genomes have exactly the same gene content, duplicated genes, including those within 1 of the 2 copies of the IR, as well as genes lacking in some of the genomes analyzed were excluded from the data set and the genomes were considered as linear molecules.
Every human develops from a single fertilised cell to become a complex organism comprised of billions of cells that can express vastly different properties and functions: cells such as keratinocytes, bone cells, lymphocytes and neurons are extremely different from each other and yet they all possess exactly the same single genome.
In sharp contrast to the charophycean lineages discussed above, the two representatives of the Charales display an extremely conservative pattern of mitochondrial genome evolution, sharing exactly the same gene content (fig. 2) and gene order (fig. 5) as well as a high proportion of group II introns (fig. 4).
We constructed the composite PON by combining different genomes because the success rate of the domain-based method is positively correlated with the size of the network and the GO term annotation of a domain is exactly the same for various genomes according to InterPro database.
Following removal of reads that either failed to align to BCM4 or aligned to more than one position in the genome, and the removal of all but one of the reads that mapped to exactly the same position on the genome (i.e. putative PCR duplicates), an average of 3.8 million reads per lane were retained for read abundance calculation.
If that were a coincidence, humans and chimpanzees would have had to endure an incalculable number of identical viral infections in the course of millions of years, and then, somehow, those infections would have had to end up in exactly the same place within each genome.
While we found that 92% of the affected genes overlapped (5,995 genes total), these genes were not always affected by exactly the same mutations in both genomes.
Half of the localizations were not consistent between all genome browsers, leaving a set of 3369 sequence tags associated with 1659 genes all assigned exactly the same coordinates on the mouse genome.
And here is where things get interesting: even our siblings (barring identical twins) don't receive exactly the same halves of our parents' genomes, which means that everyone's genome is unique.
