Random differential forms probing the (mathcal{H}_{ell}^{mathrm{coexact}}) have exactly the same orientation preference layout as those we have already met, except for a difference of "chirality" that corresponds to a global shift of the orientations.
To our surprise, the structurally preferred orientation exactly matches the orientation where SNARE complex exhibits minimal electrostatic interaction energies with fusing membranes (Fig. 2B).
This difference is not surprising, given the difficulty of aligning an artificial current dipole exactly along the orientation of the lowest sensitivity.
In this orientation, neither the group at C3 (which has now exactly the same orientation as for nat-PS) nor the C18/C19 methyl groups (which now project to the same side) can hinder the binding (or the access) of ent-PS.
The quadrupolar nature of a gravitational wave will cause a compressing-and-stretching of mutually perpendicular arms, but if a wave comes in at exactly the wrong orientation (in the detector's blind spot), the signal will be missed.
Although the way in which alterations of the central helix modulate the molecular recognition mechanism is not known exactly, the relative orientation of the globular domains seems to be of great importance.
That's vital, he adds, because for x-ray crystallography to work, researchers must produce millions of identical copies of a protein and then coax them to align in exactly the same orientation as they solidify into a crystal.
Unlike the study of Newell et al. [2], the objects were not fixed to a surface but placed in the participants' hands: participants were instructed to keep the objects in exactly the same orientation as presented and not to rotate or otherwise manipulate them.
When the crustal structures of these four enzymes were superimposed by Pandit et al [27], they all showed exactly the same orientation and interestingly less than 16% of the residues are identical in the superimposed parts, indicating that the pattern of the catalytic core is highly conserved structurally.
