Although the results are somewhat noisy, making it difficult to find the exact thermal resistance, it is clear that the thermal resistance is sufficiently small that the thermistor temperature approximately matches that of the APD itself.
To the best of our knowledge, there has only been fewcase reports of treatment failure with azithromycin for Salmonella Paratyphi A. In one report, the MIC for azithromycin was > 64 mg/L, which was assumed to be azithromycin-resistant; however, the exact mechanism of resistance has not been defined [ 15].
The exact impact of resistance of Pa strains on outcome is still on debate; some studies report association between Pa resistance and morbidity/mortality, other not.
To the best of our knowledge, the gyrA-R237H and acrR-V29G mutations have never been reported and require further investigation to determine their exact role in resistance or 'fitness' as defined by their ability to compensate for the organismal cost of gaining resistance.
That will be a tall effort in Los Angeles, which has never seemed ripe for the exact sort of resistance that has felled Olympic bids from Boston to Budapest.
However, the exact mechanisms behind resistance and susceptibility to MD are still unknown.
Although the inclusion of body size improved QTL detection in our study, the exact relationship with resistance to A. salmonicida is not known.
As well as multiple assessments, dynamic measurements may be necessary - neoadjuvant studies indicate that most clinically resistant tumours show a variety of molecular responses and these may help identify more precisely the exact nature of resistance in individual tumours.
There was a significant association (p = 0.00067, Fisher exact test) between resistance to cefepime and the presence of the CTX-M-15 allele, when compared to other CTX-M alleles data not shown.
The exact mechanism of resistance has not yet been determined, but it appears to be related to a block in early virus replication, rather than a change to the peritrophic membrane, gut receptors, or immunity (Asser-Kaiser et al. 2011).
