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The exact determinants of this perceived variation are unknown, although population and provider density, along with health care resources, may play a role.
13 Further studies are needed to investigate the exact determinants.
The exact determinants of symptom severity and outcome for patients with lower limb arterial occlusive disease are poorly understood but likely depend on the ability of the limb to adapt to atherosclerosis through development of new capillaries (angiogenesis) and expansion of collateral arteries (arteriogenesis) [ 6].
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The exact determinant that regulates which viral or cellular transcripts will interact with B5 requires further study.
Nevertheless, further investigation is clearly required to understand the exact determinant for establishing the metastasis-prone inflammatory microenvironment.
Place of birth is not an exact determinant of ethnicity but is a pragmatic alternative that is both relevant and informative in this context.
Hereby, these findings have important implications for drug discovery and 7TMR biology and illustrate the necessity of uncovering the exact molecular determinants for G protein-coupling and β-arrestin recruitment, respectively.
Further study is needed to dissect the exact sequence determinants of these regulatory differences.
While the exact cellular determinants and pathogenic molecular mediators remain elusive, the clinical picture and cytokine profile of PFAPA outline a very complex, heterogeneous, but nevertheless autoinflammatory, disease [ 55].
Thus, understanding the exact molecular determinants of TRAIL resistance and developing strategies to overcome such resistance without killing normal cells are extremely important prerequisites for the successful deployment of TRAIL as a therapeutic agent.
Although the exact genetic determinant remains to be identified, Breeuwer et al. reported that intracellular accumulation of trehalose, among other features, prevents protein denaturation and membrane fusion and these may contribute to the desiccation-resistant properties of the bacterium [ 14, 15].
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