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Chronic mesenteric ischemia (CMI) is a rare disease; however, symptomatic CMI has a risk of acute exacerbation without timely revascularization.
Finally, ciclesonide 640 mcg twice daily was as effective as oral prednisolone 40 mg once daily in improving lung function in 130 patients with acute asthma exacerbation, without causing HPA suppression (Postma et al. 2006).
The increase observed for specific genera when exacerbation symptoms appear paralleled a decrease of the same magnitude in the relative abundance for genera unrelated to this exacerbation, without major changes in the remaining bronchial microbiota.
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His symptoms persisted with intermittent exacerbations without much relief.
Tarlo et al. (2001) reported that asthma exacerbations with diary-reported colds were associated with higher levels of sulfur dioxide and nitrogen oxides compared with exacerbations without colds.
Even with 10 exacerbations without tiotropium, the average ICER is above €100 000 per QALY gained if the patient has no hospitalisation without tiotropium.
While other unknown viruses might account for those exacerbations without viral aetiology, factors other than respiratory viral infection, for example, air pollution could also be an alternative explanation.
Based on these few findings it is plausible to hypothesise that physical exercise training for patients with COPD may result in fewer exacerbations, or at least in less severe exacerbations, meaning exacerbations with a shorter duration or exacerbations without the necessity for hospital admission.
If during follow ups at three and six months, their asthma control becomes a concern (2 or more documented exacerbations without resolution (i.e. increasing preventer dose) since prior assessment or their ACQ score exceeds 2, the participant and their family physician will be notified (with participant permission).
Seventy-two patients (mean age 69 years, 58% male) with COPD exacerbation but without clinical or echocardiography-oriented evidence of acute cardiac disease were enrolled.
Data for exacerbation rates without imputation were available for 45 trials (see web extra figure S1); results were largely similar to the primary analysis, although in severe exacerbations the difference between the common comparator and combined fixed dose treatment was no longer significant (0.63, 0.40 to 1.02).
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