Exact(2)
Differences in annual FEV1 changes between sexes, history of frequent exacerbation, use of inhaled or systemic corticosteroids and use of β agonists were analysed using the Mann-Whitney U test.
Analysis of the Epidemiologic Study of CF database showed that 73.1% of patients with P. aeruginosa and 33.8% of patients without P. aeruginosa used inhaled tobramycin from 2003-2005 and that 49.7% vs. 15.9% of all patients received inhaled tobramycin for chronic vs. exacerbation use, respectively [ 23].
Similar(58)
First, the analyses of asthma treatment adherence and severe asthma exacerbation used different cohorts.
To our knowledge, this is the first article describing immunologic changes during a CRS exacerbation using several prospective measurements.
To our knowledge, this is the first description of immunologic changes in individuals with CRS comparing baseline with disease exacerbation using serial immunologic measurements.
The OGTT should be performed in the morning during a period of stable baseline health (at least 6 weeks since an acute exacerbation) using the World Health Organization protocol (5).
Irrespective of the definition of exacerbation used, the clinical diagnosis points to an acute clinical worsening that may necessitate a change in regular treatment[ 9].
Anthonisen's classification never intended to establish the severity of exacerbation using type of exacerbations (type 1, 2 and 3) but rather which patient could benefit from being treated with antibiotics.
As daily step count fell but hour's outdoors was unchanged relative to the baseline, it might be that patients with an exacerbation used transport or walked more slowly when outside the home.
Various outcomes are assessed quarterly and at exacerbation using a series of questionnaires and patient-reported outcome instruments, such as the COPD Assessment Test (CAT), 31 the Nottingham Extended Activities of Daily Living (NEADL) Scale, 32 the Council on Nutrition Appetite Questionnaire (CNAQ) 33 and the EQ-5D.
Our results and methodology will be of immediate interest to those employing domiciliary oximetry to monitor COPD and, with further validation, have the potential to facilitate objective confirmation of exacerbation using simple technology, enabling access to prompt therapy and verification of events in clinical trials.
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