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She referred rhinorrhea and lacrimation only during headache exacerbation time.
A 78 years-old woman with 1 year history of continuous and strictly left-sided headache, fluctuating in intensity (3−9 in VAS) and accompanied by conjuntival injection and nasal congestion during exacerbation time.
Although tiotropium did not significantly reduce the rate of decline in lung function, time to first exacerbation, time to first hospitalisation for exacerbations and mean number of exacerbations were all significantly improved compared with placebo (table 1) [ 12].
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23 Exacerbations 24: frequency of exacerbations, time to first exacerbation, severity and duration of exacerbations.
Time to first asthma exacerbation and time to withdrawal were compared using the log-rank test.
Time to first and second exacerbation and time to first hospitalisation will be registered on the basis of the diary card and interviews.
Primary outcomes are the rate of pulmonary exacerbations and time to pulmonary exacerbation determined by review of patient medical records.
However, trends regarding frequency of exacerbation and time to exacerbation were consistent in the esomeprazole group.
In a pre-specified sub-set analysis of patients from the UPLIFT study with GOLD stage II COPD, tiotropium improved exacerbation rate, time to first exacerbation and hospitalisation for exacerbation [ 61].
The current multicenter, single-blind RCT with a follow-up period of 6 months, evaluates the hypothesis that individualized AP's reduce exacerbation recovery time.
OC, outpatient clinic; GP, general practice; exa-rt, exacerbation recovery time; SGRQ, St George respiratory questionnaire n, number of patients; SSC, sample size calculation; pt, patient; inv, investigator.
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