In summary, exposure to inhaled chrysotile asbestos fibers was associated with an exacerbation of the development of atherosclerotic lesions in ApoE−/− mice.
Given the evidence from human epidemiological studies and animal studies, high incidence rates of breast cancer support the hypothesis that dioxin contamination in soils may contribute significantly to the etiology and exacerbation of the development of breast cancer in this region.
In the latter type, the infection may lie dormant much of the time and undergo occasional acute exacerbations, with the development of vesicles (blisters) affecting chiefly the skin folds between the toes.
Therefore, higher PlGF levels imply more inflammatory processes in the lung parenchyma, which prone to acute exacerbations or the development of pneumonia.
In patients with a pre-existing chronic process of pulmonary fibrosis, such as idiopathic pulmonary fibrosis (IPF), an acute exacerbation (AE) is the development of an acute lung injury superimposed on the underlying disease.
Hence, lactate dehydrogenase (LDH), an indicator of cell lysis, is a sputum marker of RV-induced exacerbations 4. Mechanisms involved in RV-induced asthma exacerbations and in the development of severe asthma remain to be defined in several respects, and novel treatments are needed for these severe conditions.
Possible consequences include an increase in the exacerbation risk and aggravation of COPD, the development of health-risk behavior or of a new disease, and/or the deterioration of communication with caregivers, family or friends.
33 Similarly, we expected both short and long term effects on pulmonary deaths, as smoking and smoke exposure can trigger an acute disease exacerbation and contribute to the development of chronic disease (such as chronic obstructive pulmonary disease).
Comprehensive investigation of epigenetic mechanisms prior to, during and after virus induced exacerbation could therefore reveal if component(s) of the epigenome contribute to the development of exacerbation.
Among our study patients, we did not observe increases in body weight, exacerbation of heart failure, and the development of bladder cancer after 6 months of treatment.
