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We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD.
9 This might increase the exacerbation risk and could result in worse health outcomes.
The precise relationship between psychological distress and exacerbation risk has yet to be adequately addressed however.
Mean reliever use over 1 week was predictive of long-term exacerbation risk.
This new classification distinguishes four groups of patients, based on symptoms and exacerbation risk.
Budesonide/formoterol was associated with lower short- and long-term exacerbation risk than formoterol in all reliever-use groups.
In this study, we will identify important risk predictors for health-related quality of life, exacerbation risk and mortality.
The baseline characteristics of patients stratified according to low/high exacerbation risk is summarized in Table 1.
Additionally, the results from the ECLIPSE study suggested that patients with COPD could be phenotyped according to their exacerbation risk.
For example, a high antioxidant diet reduced exacerbation risk and improved lung function compared to a low antioxidant diet [ 24].
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The International Collaborative Effort on Chronic Obstructive Lung Disease Exacerbationn Risk Index Cohorts (ICE COLD ERIC) study was designed to develop and validate such practical COPD severity indices in primary care patients with Global Initiative for Chronic Obstructive Lung Disease GOLDD) stages II IV.
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