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We examined effect modification in the NO2-asthma exacerbation relationship by stressor factors, and found significant (p <0.05) modification only by Factor 2 ('crowding and poor access to resources'); among UHF areas scoring above the median on Factor 2, each 10 ppb increase in area-average NO2 was associated with a 5.5% increase in child asthma ED visit rates.
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No studies were identified that explicitly examine this relationship to exacerbation of asthma.
There was no relationship between exacerbation frequency and any VDR polymorphisms (all p > 0.05).
Additionally, there was also a strong relationship between exacerbation frequency and MDM efferocytosis of eosinophils.
Exposures to indoor dampness and dampness-related agents have a causal relationship with exacerbation of asthma (in children).
A relationship between exacerbation frequency and symptom severity is well established on the basis of findings from prospective studies; 19 20 however, the two factors are semi-independent and patients with moderate airflow limitation can experience recurrent exacerbations.
Given the relationship between exacerbation rate and decline in pulmonary function [ 11], it would be highly significant if PR were to impact on the incidence of acute exacerbations in bronchiectasis.
As HRV is the commonest cause of colds and present in over 50% of COPD exacerbations, we chose specifically to investigate a relationship between HRV exacerbations and 25-hydroxyvitamin D deficiency.
The diversity of pesticides used in homes suggests that their relationships to exacerbation of asthma will not be uniform (IOM 2000).
Individual data thresholds to set alerts were determined, and the relationship to exacerbations, defined by the initiation of stand-by medications, was measured.
Further studies are needed to elucidate the role of increased leptin and decreased IGF-I levels during COPD exacerbations and their possible relationship with energy imbalance observed in these patients.
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