In addition, in a double-blind placebo-controlled randomized study, it was shown that treatment with methylprednisolone was associated with higher blood glucose levels and higher daily insulin doses in patients with COPD exacerbation needing mechanical ventilation [20].
In PERCEIVE, 89% of patients who had experienced an exacerbation needed to see their doctor, and 21% required hospital admission [ 7].
In addition, in a double-blind placebo-controlled randomized study, it was shown that treatment with methylprednisolone was associated with higher blood glucose levels and higher daily insulin doses in patients with COPD exacerbation needing mechanical ventilation [ 20].
However, whether CO inhalation increases the risk of COPD exacerbations needs to be determined.
Finally, whether AZLI offers clinical benefit for the treatment of acute CF respiratory exacerbations needs to be determined by prospective studies.
Therefore, the balance between the protective and pathologic effects of neutrophils in the course of virus-induced asthma exacerbations needs to be clarified when drug treatment to control neutrophilic inflammation is studied in the future.
Many patients with ulcerative colitis (UC) present with acute exacerbations needing hospital admission.
Baseline assessment included asthma and medical history, vital signs, physical examination, routine blood tests, chest radiography, spirometry and clinical events related to asthma within the previous year, including asthma exacerbations, need for systemic corticosteroids, ED visits and hospitalizations for asthma.
Second, the analyses regarding the association of the SNP with the exacerbation frequency need replication but this cannot at present be achieved, owing to the lack of a similarly characterized cohort.
13 14 Hence a more standardised comparison of all relevant drug maintenance strategies to prevent asthma exacerbations is needed.
