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Data about medication use, asthma exacerbation data, asthma-related healthcare utilization and events raising safety concerns will also be collected.
However, in these studies, exacerbation data were collected as adverse events.
However, the limited exacerbation data from these studies are encouraging and in line with results for other LAMA+LABA combinations [ 25].
There is also controversy about the application of meta-analysis of COPD exacerbation data as original trials may report outcomes heterogeneously.
The ΔmTSS >0.5 was observed within the first year of ADA discontinuation in two patients, so that their radiographic progression was determined by linearly extrapolating changes using their radiographic scores at exacerbation (data not shown).
In 55 subjects with paired exacerbation data, qPCR bacterial load fold change at exacerbation in M catarrhalis but not H influenzae correlated to changes in sputum TNF-α and IL-1β concentrations.
Similar(51)
COPD exacerbations data are presented in Additional file 1.
In terms of preventing COPD exacerbations, data for current twice-daily LABAs are mixed.
These two patient subgroups were similar regarding age, sex, body mass index, pulmonary function testing variables and exacerbation rate (data not shown).
The study profile is illustrated as Figure 1 which shows that of the 40 patients given oximeters, 31 had sufficient symptom and exacerbation free data for analysis in the stable state.
This cut-off for exacerbations reflects data in COPD which demonstrates that it takes 14 days to recover from an exacerbation [ 26].
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