The researchers believe that the attempts by the authorities to declare a "war on drugs" have merely pushed the traffickers into other remote areas, exacerbating pressures on vulnerable and ecologically important forests.
Currently more than half of the global population reside in cities which influence the global biogeochemical cycles and climate change, substantially exacerbating pressures on urban pollution, water quality and food security, as well as operating costs for infrastructure development.
"When taken together with reduced funding for local government, and the damaging knock-on effect for social care, this can only exacerbate pressures on the wider NHS which translate into delays and distress for patients and service users".
But analysts said GM's own actions would exacerbate pressures facing already fragile suppliers.
These events, combined with volatile and often elevated fuel prices in recent years, have exacerbated pressures on households already struggling to access basic and social services.
Internationally, the pressure the BBC is under to commercialise its news service, after being given full funding responsibility for the BBC World Service and extra obligations such as funding licence fees for over-75s, will "exacerbate pressure" for the corporation to compete for advertising and sponsorship outside the UK.
Janina Gray, the Salmon and Trout Association's head of science, said: "The water use of the UK shale gas industry could exacerbate pressure on rivers and wetlands, particularly on sensitive water bodies and those already suffering from over-abstraction, such as chalk streams, and this adds yet further pressure on declining fish populations - the Atlantic salmon being a prime example.
Competition between cultivation and pasture within the reserve exacerbates pressure on grazing, replicating some of the natural resource conflict issues faced outside the reserve.
AMPKα2 deficiency was shown to enhance myocardial ischemia/reperfusion injury in a mouse model with cardiomyocyte-specific overexpression of a mutant AMPKα2 catalytic subunit [83], and to exacerbate pressure overload induced left ventricular hypertrophy and dysfunction in AMPKα2 knock-out mice [84].
In addition, humoral, hormonal and/or sympathetic nerve activities further exacerbates pressure and/or volume overload to affect progression of the LV remodelling.
Concern was still expressed, however, about waiting times and the possibility that a primary care intervention may exacerbate pressure on secondary care services.
