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Substitution of WT infection by intranasal treatment with purified active PT was sufficient to replicate the exacerbating effects on PR8 infection in BALB/c and C57/BL6 mice, but the effects of PT were lost when toxin was administered 24 h after virus inoculation.
Finally, given the strong association between OSAS an ED, it may be clinically relevant to screen patients with ED for possible OSAS, particularly given data showing that commonly used therapies for ED treatment, such as either phosphodiesterase inhibitors or testosterone replacement, have known exacerbating effects on obstructive breathing during sleep.
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This could account in part for the exacerbating effects of radiation therapy on GBM progression (Seyfried et al., 2010).
We also found that a single dose of purified PT administered intranasally was able to replicate the exacerbating effects of B. pertussis infection on influenza virus infection independent of the bacteria.
Adding to this the exacerbating effects of topical glaucoma medications on ocular surface aggravate the patient's treatment compliance and therefore consequently reduce adherence [ 37, 46].
In the present study, the exacerbating effects of Tar and/or H-ASD on OVA- induced lung eosinophilia were investigated using ICR mice.
I hardly share Barnes's lust for Renoir, but I will now never forget that artist's exacerbating effect on Cézanne, whose cobbled form and pensive color tense against Renoir's work as if leaning into a hot, fragrant wind.
This has an exacerbating effect on minorities.
But continuation of the status quo, which includes expanding and open-ended settlements, punctuated by increasingly horrific wars, has had and continues to have an extremely exacerbating effect on the region and the world.
Together, these data demonstrate that only enzymatically active PT has an exacerbating effect on influenza disease.
This is in accordance with the idea that disturbances have an exacerbating effect on cancerous progression.
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