We went on to examine whether expression of Rpn4* could exacerbate the sensitivity of checkpoint mutants to DNA damaging agents.
In addition, some inconsistent physiological results between stress effects have been referred, one study suggests that drought can enhance the PSII tolerance of plants to high temperature, but others reported that drought would exacerbate the sensitivity of heat stress on plant photosynthesis [ 18, 19].
Double mutants of dna2 -1 with tos9 ∆, swi4 Δ, ckb1 Δ, rps10A ∆, or rad27 Δ showed increased phleomycin sensitivity relative to the relevant single mutants, indicating that deletion of any of these five genes exacerbates the phleomycin sensitivity of dna2 -1 mutants.
Furthermore, hrk1 mutation did not exacerbate the increased sensitivity of the hog1Δ mutant to high temperature and SDS (Fig. S5).
From our oxidant and antioxidant experiments we observed a clear pattern: both oxidants exacerbated the galactose sensitivity of GALT-null but not the control Drosophila and, conversely, both antioxidants had a protective effect.
Decreasing UPS levels via genetic ablation of the transcription factor Rpn4 (Xie and Varshavsky, 2001) profoundly delayed the growth of ncs2Δelp6Δ and exacerbated the stress sensitivity of ncs2Δ, ncs6Δ, elp2Δ, and elp6Δ strains, whereas it had little effect on growth in a wild-type background.
Arguably the problem is exacerbated by the sensitivity of innovators to fairness; imitators do get a free lunch, after all.
The sensitivity of PPU to small changes in the (local) pressure distribution exacerbates the problem.
This exacerbates the problem".
Progress exacerbates the problem.
