Our finding may suggest that previous ovarian surgery exacerbates the depletion of ovarian reserve in the patients with endometriosis regardless of inter-surgeon variability.
The main difficulty associated with the approach described in the previous paragraph is however that, as the number of targets increases, the corresponding growth in the dimension of the state space is likely to exacerbate particle depletion, thus causing the detection/tracking filters to diverge if the number of particles is kept constant.
In Tet-treated cells, we observed the glucose uptake was marked repressed by an unknown mechanism, which further exacerbated energy depletion upon autophagy inhibition.
In the present study we found induced metallothionein expression also in the embryo after maternal VPA administration (Table 2), possibly exacerbating the depletion of Zn2+ available for developmental processes.
This relaxed silencing is further exacerbated upon depletion of the PRC2 member EED, indicating that PRC2, possibly via its H3K27me3 catalytic activity, plays a role in the maintenance of I-XCI in the TE lineage [ 23, 24].
PARP is an important enzyme for the repair of DNA damage and maintenance of genomic integrity; however, increased PARP activity can exacerbate the depletion of cellular energy stores under certain conditions promoting cell death [ 114].
Serotonin depletion exacerbates changes in striatal gene expression following quinolinic acid injection.
This study demonstrates that nigrostriatal dopamine depletion exacerbates the neuropathic pain resulting from CCI-IoN.
10.7554/eLife.09221.004 Figure 2. SC depletion exacerbates neuromuscular disruption induced myofiber atrophy.
10.7554/eLife.07759.013 Figure 5. LAP2 depletion exacerbates the progerin-induced proliferation defect whereas specific overexpression of LAP2α rescues it.
We have included some sentences for this observation (in the subsection "SC depletion exacerbates myofiber atrophy and induces connective tissue accumulation in skeletal muscles after neuromuscular disruption").
