Sentence examples for exacerbates central from inspiring English sources

Thus, this study aimed to determine whether exercise exacerbates central sleep apnoea with exposure to normobaric hypoxia.

Together, these results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in Multiple Sclerosis.

Interestingly, while several studies have shown that passive hyperthermia is associated with reductions in VA, 13 14 16–18 the role of exercise-induced hyperthermia in exacerbating central fatigue is unclear.

In a triple-transgenic mouse model of Alzheimer's disease, repeated challenges with lipopolysaccharide were shown to exacerbate central nervous system inflammation and to cause increased tau phosphorylation [28].

Much of this shift can be exacerbated by central government policy, over which councils have no control: the impact of the benefit cap in exporting the poorest from from inner-city areas.

Heart failure may lead to hypoperfusion and hypooxygenation of tissues and this is often exacerbated by central and obstructive sleep apnoeas associated with recurrent episodes of systemic hypoxia which triggers release of ATP within the CNS circuits controlling sympathetic outflow.

Taken together these data suggest that in heart failure hypoperfusion and hypooxygenation of brain tissues (often exacerbated by central and obstructive sleep apnoeas) may result in an increase in extracellular concentration of ATP in the RVLM leading to higher level of activity of sympathoexcitatory neurones and increased central sympathetic drive.

Type 2 diabetes is a metabolic disorder characterized by chronic hyperglycemia resulting from a progressive insulin secretory defect on the background of insulin resistance, usually leading to absolute insulin deficiency, which results in complex phenomena exacerbated by central obesity [ 2], and increases the risk for atherosclerosis and related cardiovascular disease [ 3- 6].

Increasing evidence suggest that activation of the peripheral immune system exacerbates the discordant central inflammatory response and synergistically drives neurodegeneration.

Recent studies suggest that activation of the peripheral immune systems exacerbates the discordant central inflammatory response in aged or genetic predisposed brains.

4 Because ageing reduces daily energy requirements, the decreased physical activity also associated with normal ageing exacerbates the onset of central obesity and loss of lean muscle mass.