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When tested in vivo, L. plantarum and LGG exacerbated the development of DSS-induced colitis and caused the death of treated mice, while, conversely L. paracasei was protective.
Administration of rIL-22 significantly accelerated and exacerbated the development of proteinuria.
Administration of anti-TIM-2 mAbs in early phase, but not late phase, significantly exacerbated the development of CIA.
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The unstable alveoli that develop 60 minutes following injurious MV are pathologic and will exacerbate the development of VILI [ 21].
Over-use and misuse of antibiotics exacerbates the development of drug-resistant bacteria, often called superbugs.
Associations have been described previously between environmental toxins, body weight, and diabetes [8], [51] leading to suggestions that exposure to certain environmental pollutants may initiate or exacerbate the development of obesity [17] and associated health problems [33].
In addition, adipose tissue macrophages (ATMs) and cytokines are able to keep preadipocytes in quiescent stages, and an imbalance in this mechanism could exacerbate the development of obesity and insulin resistance [4] [5].
In keeping with these observations are data showing that treatment with anti-GITR also exacerbates the development of autoimmune and allergic disorders including autoimmune gastritis [1], experimental autoimmune encephalomyelitis (EAE) [23], experimental collagen-induced arthritis (CIA) and asthma [24].
This observation suggests that the severity of metabolic syndrome exacerbates the development of stones and cancer.
Thus, genetic differences in the dopamine system genes may exacerbate the development of neurocognitive impairment in an individual [ 5, 35].
This could play a role in pathogenesis of "total insulin resistance", thus exacerbating the development of type 2 diabetes.
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