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Physical exercise at a moderate intensity also has a compensatory effect against the exacerbated production of reactive oxygen and nitrogen species responsible for the oxidative damage.
Whereas the generation of these proinflammatory molecules favors the reduction of the parasitic load, their exacerbated production participates in the development of malaria immunopathology [2], [5].
Therefore, unbalanced red/ox homeostasis, as found in diabetes, will determine an exacerbated production of superoxide anion instead of NO, leading to diabetic-associated vascular dysfunction.
Despite the fact that their peak concentration may reflect an exacerbated production, these levels do not necessarily stand for enhanced bioactivity.
Sepsis and non-infectious SIRS are associated with an exacerbated production of cytokines, as assessed by their presence in biological fluids [ 96].
It is known that an intrinsic characteristic such as genetic background can also influence the production of cytokines, as demonstrated for TNF and IL-6, whose exacerbated production favoured tissue damage in ML 12, 13.
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In contrast, inhibitors of the TF-initiation complex reduce proinflammatory cytokines such as interleukin-6 in lethal sepsis models induced by high-dose endotoxin [ 26, 27], indicating that signaling by coagulation proteases contributes only to exacerbated cytokine production, and not to the initial inflammatory response.
S. suis is not considered a primary pulmonary pathogen, but an exacerbated local production of proinflammatory mediators during a co-infection with influenza virus, as strongly suggested by the results obtained in the present study, may be important in the pathogenesis and clinical outcome of S. suis associated respiratory infections.
CD8+ T cell-depleted mice also had a higher number of apoptotic cells in hepatic inflammatory foci and showed exacerbated IFN-γ production by spleen cells after specific stimulation.
Although few articles have reported the efficacy of non-invasive techniques in augmenting sputum production in exacerbated alert COPD patients [ 5- 7], these options may not have been successful in patients with severe COPD exacerbations with depressed sensorium and inefficient cough.
If poultry owners rely mainly on mortality (due to exacerbated disease) or reduced egg production as visible criteria for detection, the virus could spread long before infection is suspected or confirmed.
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