Sentence examples for exacerbated phenotype from inspiring English sources

Interestingly, while observing muscle histology of Sgca null:Mlc1f-Nfix2 mice, we encountered a strong phenotypic variability, with impressive exacerbation of the phenotype in some cases, and only a milder exacerbated phenotype in others.

Nevertheless, the exacerbated phenotype observed in the double Sgca null:Mlc1f-Nfix2 mice, where Nfix is overexpressed specifically in muscle cells, clearly supports the evidence that a slow regenerating and a slow twitching dystrophic musculature is at the basis of the amelioration/rescue observed.

Increased plectin expression was not found to explain the lack of an exacerbated phenotype in ms-DKO mice.

The lack of an exacerbated phenotype in ms-DKO mice suggests γcyto-actin and dystrophin function in a common pathway.

This exacerbated phenotype suggests that compromising the pericellular sheath worsens the effect of Pacsin3 depletion and that Pacsin3 may not play a direct role in exocytosis and assembly of the sheath.

The exacerbated phenotype was rescued by administration of PKC inhibitor or hydralazine, which was proposed to inhibit PKC-dependent ERK phosphorylation.

The transgenic overexpression of tomoregulin-1 increased the survival rate, improved the cardiac geometry and functional parameters of echocardiography, and decreased the degree of cardiac hypertrophy of the TAC mice, whereas knockdown of tomoregulin-1 expression resulted in an opposite phenotype and exacerbated phenotypes of cardiac hypertrophy induced by TAC.

An examination of wing disks also indicates that dSno coexpression does not rescue but rather exacerbates phenotypes due to UAS.DN-Notch and UAS.MamN.

Increasing growth temperature generally exacerbated this phenotype.

Activation of Myc in the presence of TSA exacerbated the phenotype of K14MycER epidermis (Fig. 6D,H,L,P,T).

Supplementation of the diet with a high concentration of Mg2+ exacerbated the phenotype, resulting in growth arrest during the larval period.