Sentence examples for exacerbated pathology from inspiring English sources

Nevertheless, injuries subsequent to the degenerative process progressively created a chronic inflammatory state in the brain of ageing MPSIIIB mice (8 months), which was independent of TLR4 and MyD88, and which in turn may have exacerbated pathology.

Rodents fed Zn2+-deficient diets suffer exacerbated pathology in models of colitis and polymicrobial sepsis.

IL-6/STAT3 signalling drives TH-17 cell differentiation, and hyperactive gp130/STAT3 signalling in the gp130F/F mouse promotes exacerbated pathology.

The exacerbated pathology was reversible through the clearance of Ec worms via praziquantel treatment [ 151].

These animals presented an exacerbated pathology that was established early from the 2nd week postinfection (p.i).

Importantly, the 4xTg mice exhibit accelerated cognitive decline compared with 3xTg-AD mice and single-transgenic SNCA mice, suggesting that the exacerbated pathology is clinically relevant.

However, analogous to herpes simplex virus and toxoplasma (reviewed in 49), the possibility exists that despite exerting potent antimicrobial activity, NO could still exacerbate pathology.

The presence of copper in mildly acidic conditions induces aggregation of the Aβ peptide [13] and may exacerbate pathology linked to Aβ deposition.

Neutralization of IL-23 or IL-17 during disseminated and oral candidiasis as well as during pulmonary aspergillosis exacerbates pathology, demonstrated by decreased neutrophil infiltration, increased fungal burden, and reduced levels of chemokines [40] [42].

Therefore, therapeutic strategies require careful consideration as enhancing autophagy induction in patients with advanced disease may exacerbate pathology; indeed, upregulating autophagy in other diseases with lysosomal impairment exacerbates pathology and behavior deficits [ 68].

GFAP accumulation may also exacerbate pathology through the formation of positive feedback loops that impact both synthesis and degradation (Messing et al., 2012).