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Repeated LPS challenge can produce tolerance depending on dose and timing [ 40] and there is evidence for diminished systemic responses to LPS after three to four doses, while CNS synthesis of IL-1α, TNF-α, IL-6, IL-12 and CCL2 was maintained or even exacerbated in the same animals [ 41, 42].
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"That kind of problem is exacerbated in the terrorist context".
Notably, these deficiencies are exacerbated in the frail elderly [ 32].
Tensions between Downing Street and grassroots Conservatives, which have focused on the issue of Europe in recent weeks, have been exacerbated by the same-sex marriage proposals.
These defects are not exacerbated in double mutants, supporting that synaptojanin and endophilin function in the same pathway.
So the trend was exacerbated in recent years".
To examine if loss-of-function phenotypes could be exacerbated by removal of genes that function in the same pathway, zygotic embryos of the genotype elmo19F3/elmo19F3; spg242/spg242 were analyzed.
AZT treatment occurred at the village level, which might have exacerbated similarities in malaria risk among participants in the same village and created village-level clustering (25 ).
Repeated measures analysis of weekly performance in the same animals revealed clearly exacerbated neurological decline as measured by both tasks (Fig. 7c and d).
Sitting in a pressurized cabin for hours in the same position will reliably exacerbate stomach issues such as bloat and gas.
Similarly, chronic infections in the same body part may exacerbate morbidity (e.g., hepatitis viruses A and C [ 13]).
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