His disappointment was exacerbated at the time by a breakdown in communication with the management, a criticism that cannot be aimed at the more diplomatic Di Matteo, who has been charged with introducing new creative, goalscoring talent into midfield while maintaining relations with the club's long-serving personnel.
Intracellular acidosis during acute myocardial ischaemia results in intracellular calcium overload and subsequent mitochondrial calcium accumulation, which is exacerbated at the time of reperfusion and results in MPTP opening (Ruiz-Meana et al., 2006).
59 In addition, the EWTD has been associated with real concerns about the adequacy of the training of doctors given their reduced exposure to patient care, and the lack of experience of the patient journey, imposed by adherence to the EWTD. 4 This is potentially exacerbated at the same time by the constraints on the overall duration of training imposed by other EU directives.
The survey of QA practices in 53 European PGD laboratories revealed that only 33% of laboratories described themselves as 'accredited, certified or preparing for accreditation', and 66% as not participating in EQA, a problem which was exacerbated at that time by the absence of existing PGD-specific schemes.
The hardship was exacerbated by the time of year.
Little-known works by Matta-Clark, whose estate is represented by the Zwirner gallery, dominate the new show, mainly drawings of abstracted tree forms and photographs of gaudy street and subway graffiti — a populist novelty then, which at once exacerbated and brightened the time's cascading urban blight.
The study data provide further support of the "weathering hypothesis," adverse maternal health may be secondary to persistent life course stressors that are not modifiable, and in fact may be exacerbated, with private insurance at the time of childbirth.
His administration's bumbling is exacerbating those doubts just at the time when economic jitters are putting a greater premium on domestic-policy skills.
The finding that PrPc-silencing could exacerbate disease when delivered at the time of immunization, onset of disease, or at later stages of autoimmunity strongly suggests that PrPc is an important negative regulator of T cell responses.
Guns, many of the adults agreed at the time, exacerbated the threat of violence they were acquired to prevent.
Tensions were further exacerbated when Daryl Gates, the police chief at the time, suggested that black people might be more likely to die from a chokehold than "normal people".
