Inhibition of autophagy also exacerbates aging phenotypes in muscle, such as mitochondrial dysfunction, oxidative stress, and profound weakness.
Together, these results indicate that a decrease in SOD2-dependent antioxidant defence does not exacerbate aging in the context of telomere dysfunction.
We therefore have analysed whether an increase in mitochondrial derived oxidative stress in response to heterozygous deletion of superoxide dismutase (Sod2+/-) would exacerbate aging phenotypes in telomere dysfunctional (mTerc-/) mice.
To understand whether aging of hematopoietic niches disturbs contents of platelet's granules, which could exacerbate aged stem cell niches in systemic manner, will give potential insights into molecular cues present in young circulation.
New media has exacerbated age-old parenting problems, Roth thinks.
DOI: http://dx.doi.org/10.7554/eLife.06184.015 We submitted the mice to a series of analyses to test if Siglec-E−/− animals exhibited exacerbated age-related defects.
Thus, aging is associated with Nrf2 dysfunction in the vasculature, which likely exacerbates age-related cellular oxidative stress and increases sensitivity of aged vessels to oxidative stress-induced cellular damage.
There is mounting evidence that HIV exacerbates age-associated cognitive decline.
Such pathophysiologic changes may exacerbate age-related physiologic changes in joint function attributable to genetic characteristics, age, sex, and health status, leading to greater cartilage damage.
However, crosslinking of membrane proteins by alpha-oxoaldehydes is enhanced; this effect may exacerbate ageing and decrease the lifetime of erythrocytes in circulation.
