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Defective functioning of the autophagic-lysosomal pathway, dysregulated mTORC1 signaling, and impaired lipid metabolism in the liver affect each other and may further exacerbate vulnerable lipid homeostasis and insulin sensitivity in obesity (Um et al., 2004; Khamzina et al., 2005; Yang et al., 2010; Samuel and Shulman, 2012; Han et al., 2015; Martinez-Lopez and Singh, 2015).
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Identification of particularly vulnerable regions can serve as an entry point for both understanding and addressing the processes that cause and exacerbate vulnerability (Yohe and Tol 2002; Brooks and Adger 2003; O'Brien and others 2004).
Another possible mechanism is that exposure to suicide may induce or exacerbate depression in vulnerable adolescents, a vulnerability that may manifest as a suicidal behaviour through the mechanism of complicated bereavement rather than through contagion and imitation [ 14].
A study by Litchford et al [ 51] showed how cognitive dysfunction further exacerbates the already vulnerable nutritional state of an older population.
A recent report by the investment bank Bank of America Merrill Lynch suggested the increasing use of robots could leave up to 35% of UK jobs vulnerable, and exacerbate inequality.
Except for empirical studies that reveal health inequality, equitable healthcare service has not been put into effect in practice, which further exacerbates outcome inequity for vulnerable older people.
However, recent in vitro evidence suggests that expression of mHtt in astrocytes may directly affect astrocyte function, exacerbating the dysfunction of vulnerable striatal neurons (13).
They warned that cuts would exacerbate hardship among the most vulnerable.
The current financial crisis could exacerbate the conditions of existing vulnerable groups as well as create new ones.
As chronic sleep deprivation can precipitate the manic episode, insomnia (a very common side-effect of sibutramine) might exacerbate manic symptoms in our vulnerable patient.
Need for interventions The recent increase in food prices is likely to exacerbate any problems by forcing vulnerable households to buy more affordable but less nutritious food.
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CEO of Professional Science Editing for Scientists @ prosciediting.com