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The unstable alveoli that develop 60 minutes following injurious MV are pathologic and will exacerbate the development of VILI [ 21].
Associations have been described previously between environmental toxins, body weight, and diabetes [8], [51] leading to suggestions that exposure to certain environmental pollutants may initiate or exacerbate the development of obesity [17] and associated health problems [33].
In addition, adipose tissue macrophages (ATMs) and cytokines are able to keep preadipocytes in quiescent stages, and an imbalance in this mechanism could exacerbate the development of obesity and insulin resistance [4] [5].
Moreover, hypothalamic autophagy defect can promote inflammatory activation to exacerbate the development of HFD-induced obesity and metabolic comorbidities [ 40].
Thus, genetic differences in the dopamine system genes may exacerbate the development of neurocognitive impairment in an individual [ 5, 35].
Match-play tennis in the heat does not exacerbate the development of oxidative stress, but significantly increases antioxidant status.
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Over-use and misuse of antibiotics exacerbates the development of drug-resistant bacteria, often called superbugs.
When tested in vivo, L. plantarum and LGG exacerbated the development of DSS-induced colitis and caused the death of treated mice, while, conversely L. paracasei was protective.
In keeping with these observations are data showing that treatment with anti-GITR also exacerbates the development of autoimmune and allergic disorders including autoimmune gastritis [1], experimental autoimmune encephalomyelitis (EAE) [23], experimental collagen-induced arthritis (CIA) and asthma [24].
This observation suggests that the severity of metabolic syndrome exacerbates the development of stones and cancer.
Administration of rIL-22 significantly accelerated and exacerbated the development of proteinuria.
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