Clinical signs exacerbated over time and included progressive akinesia, priapism (males), hunchback, and stiff tail.
This phenotype exacerbated over time, cosegregates with the first heterozygous nonsense mutation p.R469[R,X] reported to date for the GR, replacing an arginine (CGA) by a stop (TGA) at amino-acid 469 in the second zinc finger of the DNA-binding domain of the receptor.
The reduction in D3 was exacerbated over time, until, by day 15, levels were reduced to less than 15% of the vehicle-treated samples.
"People change over time.
Moreover, a child's psychosocial problems and parenting stress exacerbate each other over time [ 5].
The current study was designed to determine whether changes in muscle fibers persisted, were exacerbated, or resolved over time.
He suffers a broken hip, leaving him with a permanent limp, but more awful, a serious head injury that drove skull fragments into his brain and seems to have, over time, exacerbated his lifelong depression.
On the contrary, if neurological health is compromised, estrogen exposure over time exacerbates neurological demise.
These divergent patterns of change over time exacerbated the differences in response rate between SHR and control strains at low rates of reinforcement.
