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There has been substantial progress in evolving adaptive trial methodology, however these have seldom been translated to clinical trials.
A chemoprevention (CP) strategy has evolved for conducting efficient clinical trials for prostate cancer (PCa) prevention.
Over the years the combination has evolved from trials with cellophane, ceramics, metal to metal.
This might give clues to evolving attractive therapy for future clinical trials.
AMcG: Evolved trial, research questions, design and outcomes.
Clinical trials for infant ALL have evolved significantly over time, with each stage providing vital contributions to the biological and therapeutic advances that have been achieved.
There is no conclusive evidence for using bisphosphonates in active Charcot foot, and our understanding is evolving as more trials are currently underway.
Techniques evolve by trial and error; living things survive through effective adaptation – there can be design without the necessity for a conscious designer.
ISO tank containers have evolved by trial and error.
The origins of other kitchen tools are more enigmatic, having evolved by trial and error.
Years passed by, and my leadership evolved by trial and error.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com