Sentence examples for evolving trial from inspiring English sources
We suggest that debates about the research/treatment interface in trials need to become more attuned to the conditions in locations of their conduct, views and experiences of actors involved and evolving trial methodologies.
There has been substantial progress in evolving adaptive trial methodology, however these have seldom been translated to clinical trials.
AMcG: Evolved trial, research questions, design and outcomes.
The effect on hard endpoints offered by cinacalcet versus placebo, on top of traditional therapies against SHPT (VDRA and phosphate binders), was recently investigated by the EVOLVE trial [ 100].
Thus, the EVOLVE trial was not designed to assess a head to head VDRA and cinacalcet but rather the impact of cinacalcet on survival in addition to the more heterogeneous ongoing treatments of SHPT.
Recent post hoc analyses in the frame-work of the Evaluation of Cinacalcet Hydrochloride Therapy to Lower Cardiovascular Events (EVOLVE) trial [ 7] suggest that cinacalcet may reduce the incidence rate of CUA in the dialysis population.
Unlike the EVOLVE trial, there was no possibility of cross-over of medication between the two arms, since cinacalcet was not commercially available in Korea during the study period [ 23].
The clinical impact of serum phosphorous reduction on the relevant outcome is far from being established, especially in light of the recently published results of the EVOLVE trial [ 2], and future studies should address whether high-bone turnover attenuation increases survival among CKD-5D subjects.
Early clinical trials are no exception, with efforts to improve the eventual success rate of late stage trials through evolving phase I trial methodologies, the addition of extensive pharmacodynamic studies, and early adoption of patient selection strategies.
The origins of other kitchen tools are more enigmatic, having evolved by trial and error.
Techniques evolve by trial and error; living things survive through effective adaptation – there can be design without the necessity for a conscious designer.
