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Conversely, when sources of systematic error are reduced (excluding rapidly evolving sites and/or rapidly evolving lineages), this data set lends support to Mandibulata.
Third, observing lower diversity in slowly evolving sites is likely to result from restricted haplogroup distribution, which is not a particularly conspicuous feature of the Finnish mtDNA pool.
Accordingly, we excluded the fast evolving sites of lys2.
We therefore investigated the influence of fast evolving sites.
In both cases only neutrally evolving sites were considered.
It analyzes patterns of sequence variations and mutations in a multiple sequence alignment, and separates the slowly evolving sites from the fast evolving sites.
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The selection model (M2a) allows for a third category, ω2 > 1, of adaptively-evolving sites with relative weight p2.
However, I am not sure that in practice there is no statistical bias toward less diversity in slow-evolving sites.
Only co-evolving sites with r ≥ 0.5 were considered significant.
The method was used to detect co-evolving sites in vif.
Among the co-evolving sites, we also identified structurally and linearly distant sites (e.g. 14 K and 86D).
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