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Paul's grassroots supporters were uneasy about his evolving positions on key issues.
He delivered a sharp criticism of Mr. Romney's evolving positions on abortion and his support for gay rights.
Still, Roosevelt argued that he had lost the battle but won the war, as turnover and evolving positions led to a court more disposed to his measures.
Those most optimistic about the outcome are drawing hope from the evolving positions of the airlines and the aviation industry, which are pressuring governments to reach a deal to avoid a tangle of potentially conflicting global regulations.
The ConSurf analysis identifies P42, V53, E74, D79, D97, T101, W127, A151, F159, R162, V164, and D165 as the most hypervariable and rapidly evolving positions (Figure 6A).
Let s be the total number of neutrally evolving positions.
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Prior modeling showed that a Z-score of 4 is the minimum value that reliably identified co-evolving positions in in silico-generated alignments [35], and so this Z-score value was chosen as our minimum level of significance.
The predicted positions are scattered across the sequence and only the C-terminal is free of putative co-evolving positions.
The biochemical severity of the inter-specific amino acid changes is also modulated by natural selection, with the fast-evolving positions containing more radical amino acid differences among species.
These approaches, in essence, search for correlated evolutionary events among sites, i.e. at two co-evolving positions, the substitutions occur in a pattern that is different from that expected by chance for two independently evolving sites.
Fast-evolving positions for each dataset were identified individually using a discrete gamma rate category and sites belonging to the most rapidly evolving eighth gamma category were removed.
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