Moreover, it will move us ever close to designed biomacromolecular devices that behave and perform like naturally evolved functionalities.
Thus, as outlined above, it appears that the evolutionary origin of translation is to be sought along the exaptation route, i.e., by retrodiction of the ancestral functions of various components of the translation system that would allow them to evolve functionalities enabling their recruitment for translation.
We interpret the more variegated modular arrangement of metabolism as a trace of evolved functionality.
We consider the case that viable replicators can evolve functionality through either individual or population based diversity [ 13- 15]- eg. all replicators perform all functions by themselves (like a Swiss army pocket knife) or different functions are divided over different replicators, the latter being an ecosystem based solution.
"We'll be evolving this functionality considerably by letting users filter by popularity and other factors," Hendrickson says.
Small scale (SSD) and whole genome (WGD) duplications provide the raw genetic material on which mutation and selection act to evolve new functionalities.
We invite all those involved in bioinformatics training either to register and join, or simply to browse and provide feedback, so that the site can be improved and can evolve new functionalities.
Adaptive advantages include the acquisition of novel gene combinations which can in some cases promote heterosis [ 13], the duplication of gene functions which can provide an element of buffering, and the potential to evolve novel functionality which were predicted by McClintock as "genomic shock" [ 1, 14].
The database infrastructure has likewise evolved, increasing functionality especially for managing digital media.
In the second case, methods are created with a single purpose, and as the system evolves, more functionality is added until the method becomes smelly.
