Clearly, there are multiple evolved constraints that normally prohibit clonal escape; multi-cellularity would not have survived as a highly successful, emergent condition otherwise.
Thus, in stark contrast to TRIM41 and its RING domain that has been evolving under constraint, we find that TRIM52 has been rapidly evolving throughout primate history, with much of that selection acting on the expanded RING domain.
As we continue to pay close attention to these changes, it's important to monitor necessary details such as evolving legal constraints.
The versioning system includes integrity management facilities that allow evolving design constraints to be captured flexibly at individual component/object level.
During that period, iteration between evolving engineering constraints and the relative science potential of candidate sites led to consensus on four final sites.
These models are powerful because they capture higher order correlations induced by mutations evolving under constraints and help quantify the connections between protein sequence, structure, and function maintained through evolution.
In conclusion, these analyses indicate that the UCP1 phylogeny exhibits large divergent selection pressures, which may principally involve the Eutherian UCP1 lineage, consistent with the possible acquisition of the new function of UCP1 through neutrally evolving, relaxed constraints.
According to Amalberti, workarounds are an inevitable feature of complex systems, and what we need to do is figure out how to facilitate the safest possible adaptations within the context of individual practice and evolving system constraints.
Taken together, these analyses clearly show that TAAR pseudogenes evolve without constraint and TAAR with intact ORF evolve under constraint, making it very unlikely that the observed functional differences result from intact but non-functional TAAR in primates.
With the bootstrapped AR as a control, 9.4% of the 12mers are estimated to evolve under constraint.
