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Nevertheless, because these often soil-dwelling bacteria have evolved to interact with eukaryotes, they generally exhibit a strong adaptivity, a versatile metabolism, and ingenious mechanisms tailored to modify the development of their hosts.
Structurally, its genome has evolved to interact with many human proteins from various cellular pathways.
A bias towards high-degree proteins in the last five distributions would suggest that B. anthracis, F. tularensis, Y. pestis have evolved to interact with higher degree proteins in the human PPI network.
Again, if the distribution for the last five sets is biased toward higher values of centrality than the distribution for the first set, we could hypothesize that B. anthracis, F. tularensis, and Y. pestis have evolved to interact with proteins with high betweenness centrality in the human PPI network.
Overall we suggest that HLA-G evolved to interact only with some of the inhibitory NK receptors to prevent an overwhelming inhibitory environment in the decidua which could lead to inadequate constructive signals essential to a proper development of the embryo.
Overall we suggest that HLA-G protein evolved to interact with only some of the NK inhibitory receptors thus allowing a control of inhibition, while permitting appropriate NK cell cytokine and growth factor production necessary for a viable maternal fetal interface.
Similar(38)
Some authors [ 57] speculate that the newly generated duplicate genes or gene families may evolve to interact with other existing gene families and promote the adaptation of organisms to new environments.
One interpretation of the conserved binding properties of LSECtin is that this receptor may bind a conserved endogenous glycan ligand, whereas DC-SIGN is evolving to interact with different pathogen glycans.
Several recent studies [14], [15] have suggested that viral proteins have evolved to preferentially interact with protein hubs (proteins with many interacting partners) and bottlenecks (proteins that lie in shortest paths between many pairs of proteins) in the human PPI network.
These results raise some questions: why has HIV evolved to preferentially interact with key host proteins?
Despite being novel to the host genome, the virus is pre-evolved to interact with it at the genetic level.
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