Sentence examples for evolved to inhibit the from inspiring English sources

Triglycerides impair leptin transport and may be adaptive, having evolved to inhibit the CNS effects of leptin during starvation.

Taken together, the examined REPA G tracts are mostly mammalian gene-specific, suggesting that they may have evolved to inhibit the splicing of a group of mammalian exons.

Normally, this condition leads to p53-dependent apoptosis, but HPV has evolved to inhibit the tumour suppressor p53 functions, indirectly by inducing its ubiquitylation and proteasomal degradation or directly by binding p53 interfering with its transcriptional activity.

Other pathogens, such as Leishmania brasiliensis, Salmonella typhimurium and Nisseria gonorrheae, have been shown to activate the lectin pathway [43], [44], strengthening the importance of studying the mechanisms that these pathogens evolved to inhibit this activation and complement killing.

Hence, there may be fitness disadvantages in retaining the ability to consume xylose that laboratory yeast has evolved to inhibit.

Vaccinia virus proteins A52 and B14 share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

It is tempting to speculate that episome maintenance proteins, found in herpesviruses of various species [41], [42], might have evolved to inhibit pMHC I presentation by interfering with production of DRiPs.

What specific mechanisms have bacterial pathogens evolved to inhibit autophagy?

To minimize the generally deleterious effects associated with retrotransposition, a number of pathways have evolved to inhibit transcription of ERVs.

The absence of I329L RNA in ASFV-infected cells until 20 hours postinfection, as shown by northern blot analysis [ 23], is difficult to reconcile with our findings; that is, a virus mechanism such as I329L, evolved to inhibit IFN and chemokine induction, might be predicted to be expressed early in virus infection.

The XIAP is the only cellular protein that has evolved to potently inhibit the enzymatic activity of mammalian caspases at both the initiation phase (casp-9) and the execution phase (casp-3 and -7) of apoptosis (Deveraux et al, 1997).