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In contrast, a positive relationship was observed between the evolutionary rate and the biochemical distances for inter-specific differences, indicating that radical changes in highly variable positions are more tolerated than in positions with low evolutionary variability.
Contrary to the prevalent view, then, enzyme function places severe constraints on residue identities at positions showing evolutionary variability, and at exterior non-active-site positions, in particular.
The entropy plot revealed the evolutionary variability of nonamer sequences across the WNV proteome (Figure 2).
We correlated this information with the evolutionary variability at the respective amino acid position (Figure 2, Table 3).
Still, this result could reflect the evolutionary variability of nucleotides at these positions as they show differences between the two pasteurellacean DUESs (Figure 4).
But due to its marked evolutionary variability, vaccines have to be reformulated so as to include the hemagglutinin protein from the emerging new viral strain.
Similar(25)
By experimentally linking differences in neuronal number and behavior, our findings could help explain how evolutionary and developmental variability of individual and species brain size may lead to perceptual and cognitive differences.
Culture historians in the middle decades in the twentieth century generally relied upon a paradigm designed to provide descriptive accounts of artifact inventories as normative markers of particularistic cultural traditions, but generally did not seek any deeper evolutionary explanations of variability.
In addition, to estimate speciation times and ancestral population sizes correctly, an evolutionary model including variability of evolutionary rates across lineages was required.
The identification of species-specific differences provides an evolutionary explanation for variability in vector susceptibility to arboviruses and suggests that understanding the costs of infection and resistance are important factors in determining the potential competence of vector populations for arboviruses.
The identification of species-specific differences provides an evolutionary explanation for variability in susceptibility of mosquito vectors to arboviruses and suggests that understanding the costs of infection and resistance, together with the co-evolutionary history of vector and virus, are important considerations when evaluating the potential competence of vector populations for arboviruses.
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