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In particular, we ask how the regulatory architecture of the gene circuit leads to noise, and whether this noise is subject to evolutionary tuning.
They can act as "evolutionary tuning knobs" which allow fast genetic adaptations on ecological timescales [[ 34] for review, see also [ 39]].
Synthetic devices are extraneous elements that are implanted in a cellular system that has used millions of years of evolutionary tuning to reach equilibrium.
Primordial genotypes would not have been adept at these actions, as they would have not had the benefit of extensive evolutionary tuning.
The global-regulator design suggested here may allow rapid evolutionary tuning of the hierarchy if repositioning of the sugars in the hierarchy is needed.
The present state of knowledge does not permit to assess whether the latter, more structural degree of freedom is actually exploited in the evolutionary tuning of molecular switch circuitry.
Similar(52)
Secondary loss of a parasitic life might have occurred but would require numerous adaptations, since the biology of these microorganisms is evolutionary tuned to be parasitic.
Nevertheless, evolutionary method tunes the consequent part many times to gradually minimize the errors.
One feature shared among living systems is their ability to cope with perturbations and remain stable, a property that is the result of evolutionary fine-tuning over many generations.
These results support the hypothesis that evolutionary fine-tuning of the cone system in birds extends to the level of spatial patterning.
The apparent correlation between gene expression and growth rate, observed under steady state conditions, is likely to reflect the evolutionary fine-tuning of these signals with the expected growth rate, rather than direct growth-dependent signals.
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