Sentence examples for evolutionary screening from inspiring English sources

In this study, to explore the correlation between hydrogen peroxide (H2O2) resistance and growth benefits in mycobacteria under stress, we developed a model for evolutionary screening of H2O2-resistant mutations in a pathogenic mycobacteria model, M. smegmatis, using a clinically important stressor, H2O2 (Fig. 1).

Conserved residues, which are usually believed to be the backbones of proteins, comprise pivotal structural and functional information accumulated during the long history of evolutionary screening.

Thus, this evolutionary screen of primate TRIM genes identified multiple new candidate restriction factors belonging to the same subfamily (C-IV) already known to harbor known antiviral genes.

Thus, our evolutionary screen for novel restriction factors among the TRIM gene family identified 15 members not previously known to be under positive selection.

Our evolutionary screen to identify novel restriction factors reveals several intriguing candidates that warrant further study to fully elucidate the role played by TRIM genes either directly or indirectly in mediating antiviral defense.

As many of the TRIM genes remain largely uncharacterized, our evolutionary screen is able to highlight candidate restriction factors based on exhibition of positive selection, a hallmark of antiviral genes at the direct interface of the host viral pathogen arms race (Daugherty and Malik 2012).

To address these problems, we have taken an evolutionary approach, screening for Dact genes in the animal kingdom and establishing their phylogeny and the synteny of Dact loci.

To our knowledge, this is the first broad unbiased (i.e. not driven by evolutionary conservation) screen for transcriptional enhancers in transgenic mice.

Our evolutionary-based screen not only documents positive selection in known TRIM restriction factors but also highlights candidate novel restriction factors, providing insight into the interfaces of host pathogen interactions mediated by the TRIM multigene family.

It usually occurs as the result of natural selection, hence by the evolutionary process of screening of the fittest phenotypes within the natural variation occurring in a population, leading to a progressive increase in favourable genotypes from one generation to the next.

Pros: Whole-animal screens, evolutionary conservation with human genome.