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Reversion to virulence and recombination with wild-type strains may compromise OV safety, therefore requiring evolutionary risk assessment studies.
Empirical systems bridge the gap from theory to clinical reality, which enables the translation of ideas and evolutionary risk analysis of drug treatment and disease progression.
Graded resource allocation strategies like that observed in L. malachurum are often interpreted as an evolutionary, risk spreading response (bet-hedging) to environmental stochasticity [ 1, 2].
Just as vaccine evaluation has been proposed to include evolutionary assessments—such as effects of vaccination on parasite transmission (Read and Mackinnon 2008)—we feel therapies which target immune-mediated virulence should likewise evaluate evolutionary risk.
Despite the limited potential for gene flow in soilborne pathogens, A. euteiches could be assigned to the group of medium-moderately high evolutionary risk pathogens (scale 5 7) [ 8], since the genetic structure of A. euteiches populations was reported to be patterned by a mixed reproduction system, including regular selfing with occasional migration of novel genotypes or outcrossing [ 74].
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Costs of the Precautionary Principle and the Derailment of Normal Evolutionary Risk-Management Innovation.
Designing a combination of gears so that unwanted changes would not arise might therefore provide a way to minimize evolutionary risks associated with fishing.
We conclude that because of the evolutionary risks posed by artificial propagation programs, they should not be viewed as a substitute for addressing other limiting factors that prevent achieving viability.
We provide a brief description of the potential evolutionary risks and benefits of artificial propagation and an overview of the relationship between artificial propagation and biological viability criteria developed to help guide recovery of salmonid ESUs (McElhany et al. 2000).
Beyond the evolutionary risks associated with AP genes, introducing genetically modified organisms into a population is likely to face major regulatory challenges from governments as well as possible community unease (McNaughton 2012; McNaughton and Duong 2014).
Calculation of the co-evolutionary risks of altered antigen-specificity of immune responses is therefore essential; might cross-reactive vaccines impose strong selection for escape mutants to make larger antigenic, and perhaps more virulent, leaps than they do naturally?
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