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The potential evolutionary repercussions of culling affect both the host and the pathogen.
To determine the evolutionary repercussions of avian culling on host resistance and influenza virulence, we model selection on a dominant allele that confers resistance against influenza.
The importance of understanding the potentially counterintuitive evolutionary repercussions of interventions has lead to modeling of vaccination [12] and treatment effects [13] on pathogen virulence.
To explore the epidemiological and evolutionary repercussions of mass avian culling, we combine population genetics and epidemiological influenza dynamics in a mathematical model parameterized by clinical, epidemiological, and poultry data.
By incorporating evolutionary repercussions of control strategies into our evaluation of management methods and agricultural practices, we may be able to minimize our long-term risk from influenza and other infectious diseases.
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Our analysis shows that a control strategy that is epidemiologically beneficial can have detrimental evolutionary repercussions in terms of reducing long-term resistance to H5N1, increasing host mortality, and selecting for elevated influenza virulence.
It may be possible to take steps that counter detrimental evolutionary repercussions.
Computational analysis of the ruminants' TP53 promoterterevealeded putative RTE-specific transcription factor binding sites (TFBS) which cause physiological and evolutionary repercussions.
If female choice itself were a product of neutral mutation [ 60], the pleiotropic repercussions of evolving linked male characters in response could create "runaway" evolutionary pressures on the male-specific DSX protein and result in the Ka and Ka/Ks patterns witnessed in our data.
Ecological, epidemiological, and evolutionary principles guide our understanding of disease emergence, epidemic spread, host-pathogen co-evolution, and the cascading repercussions of disease on the dynamics of all host-pathogen systems, whether microbial, plant, or animal, including human-based.
In particular, the repercussions of its interruption are unknown.
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