Sentence examples for evolutionary probabilities from inspiring English sources
It will be fascinating to explore more broadly the interplay of functional effects and evolutionary probabilities and how this interplay has biased the complement of extant enzymes.
As we observed functional units exhibiting a range of energetic behaviors within the AP active site, we asked the question: where does the energetic behavior of AP place it along this wide range of evolutionary probabilities?
The algorithm, like PETfold is a maximum expected scoring approach that combines the evolutionary probabilities Prev of a consensus structure, σ, given an alignment, with the thermodynamic probabilities of the associated structures in each sequence.
It is a hybrid strength/stiffness degradation model which utilizes basic probability-stress-life information (P-S-N curves) in conjunction with the evolutionary distribution of stresses on the critical load bearing plies of a laminate to determine the evolutionary probability of failure of a laminate.
Considering the limitation of probability conservative systems for the GPDEE, a novel concept of probability dissipation is introduced and a completely uncoupled partial differential equation is derived as well with respect to the evolutionary probability density function, which holds for any physical quantity of a probability dissipative system.
For proteins, this method usually involves two sets of parameters: a gap penalty and a substitution matrix assigning scores or probabilities to the alignment of each possible pair of amino acids based on the similarity of the amino acids' chemical properties and the evolutionary probability of the mutation.
The log-probability (LogPr) for a species evolutionary sequence from the ancestor is the summation of individual nucleotide evolutionary log-probabilities, and the evolutionary probability expectation obtained from Monte Carlo integration (exp(LogPr) mean), can be implemented by using moment generating function with argument one.
For the evolutionary part, we compute the expected accuracy (or overlap) EAev of a specific consensus structure σ with all possible consensus structures, which are weighted according to their probabilities: (1) Recall that Prev denotes the evolutionary probability of a structure σ' according to the Pfold SCFG as described above.
A deeper investigation into the energetics and energetic interconnections within an active site that of E. coli AP has led to new knowledge, new models for catalytic effects, and a quantitative assessment of the evolutionary probability of establishing an active site network.
Nonetheless, since the paradigmatic model fares poorly in predicting both experimental and evolutionary (HSSP) probabilities, it is safe to say that there remains substantial progress to be made in the field.
The loss of genetic variation during a phase of genetic equilibrium without a shifting climate window additionally decreases evolutionary rescue probabilities and increases the sensitivity towards low mutation rates (Table 2).
