Mycobacterium are among the oldest co-evolutionary partners of humans.
As illustrated in Supplementary Figure S2, the co-evolutionary network consists of 35 COGs with high number of co-evolutionary partners (degree ⩾50) and 536 COGs with multiple co-evolutionary partners (degree ⩾10).
We found 3,568 clusters, out of which 2,653 singleton clusters (COGs with no significant co-evolutionary partners), 326 clusters of two members, 101 clusters with three members, 42 clusters with four members, 13 clusters with five members and additional 41 clusters with at least six members up to the biggest cluster that consists of 30 COGs.
Furthermore, an evolutionary binding partner and functionally linked protein of HsPDF, MAP1D, is also overexpressed in colon cancers.
The stability of cooperation is an evolutionary paradox – partners should be selected to cheat, pursuing their own selfish interests by obtaining benefits without providing a reward in return.
"But we also think that the unconscious evolutionary aspect of partner choice should not be overlooked.
Consequently, we regard the observed flexibility not as a behavioral response to "active" male desertion, but rather as an evolutionary "backup" to partner loss.
Epistasis across the molecular interface therefore makes the evolution of the TF and the RE contingent upon the genotype and therefore the prior evolutionary history of its partner.
The findings show that the evolution of each molecule depended critically on chance events in the evolutionary history of its partner.
If the female is likely to make contact with more than one potential partner, the evolutionary cost of a bad choice can be severe, especially since a mycelium is inhibited from mating again after the mating process is completed [ 26, 48].
