Sentence examples for evolutionary modulation from inspiring English sources

This suggests that the different metal specificities of the isoforms were achieved by gene duplication and subsequent speciation by evolutionary modulation of these non-coordinating amino acid positions.

Sequence elucidation and phylogenetic analysis of MT isoforms from a number of snail species revealed that they possess an unspecific and two metal-specific MT isoforms, whose metal specificity was achieved exclusively by evolutionary modulation of non-cysteine amino acid positions.

An analysis of 18 V1Rs between M. m. musculus and M. spretus revealed dynamic modulation in evolutionary pressures, including examples of positive selection and lineage-specific pseudogenisation [ 33].

The absolute conservation of residues and domains involved in interaction, despite divergence in other parts of the N-terminus, suggests an evolutionary conserved mechanism of modulation of Shal (Kv4) subunits by accessory subunits, which predates the vertebrate evolutionary branching point of mammals and fish.

Although numerous mutational and overexpression studies have led to activation of antibiotic synthesis in S. lividans [ 48- 52], to our knowledge, none have succeeded in identifying the evolutionary transformation that led to modulation of actinorhodin synthesis.

It might therefore be interesting to follow the evolution of APRIL production in different breast carcinoma cells, representing different evolutionary stages of breast cancer and its modulation with (chemo therapy or under the action of factors affecting breast cell biology.

Subolesin, discovered and characterized in I. scapularis as a tick protective antigen [ 7- 9], is an evolutionary conserved protein which is involved in modulation of tick blood digestion, reproduction and development [ 10- 13].

The theory of antagonistic pleiotropy explains the modulation of longevity from an evolutionary point of view, and the few extant examples of antagonistic pleiotropy in C. elegans have possible connections to stress responses.

Being associated with most human and mouse genes in all conserved co-expression clusters of the ESC-critical pathways, the FRE appears to be evolutionary conserved and hence fundamental in regulating transcriptional modulation important to ESC development.

Hence, our findings suggest a paradigm of PCIs not only as transcriptional regulators, but also as evolutionary accelerators that can facilitate intron insertion perhaps via modulation of chromatin structure [29] under environmental circumstances in which transcriptional inhibition does not compromise fitness.

Lemon and Griffiths (2005) suggest, in fact, that this predictive modulation of sensory input is the evolutionary precursor to direct corticospinal control of motor neurons (see below).