Sentence examples for evolutionary filtering from inspiring English sources

Given the liver's major contribution to the detoxification of xenobiotics and the well established species-specificity of the proteins involved in the process (Gonzalez and Nebert, 1990), these results suggest that evolutionary filtering of CRMs has the potential to enrich for both conserved and species-specific biological pathways.

For other matrix families, different thresholds/slide amounts appeared more successful, and for some matrix families (e.g. O$VTBP, representing TATA boxes), no combination of slide amount/tree length appeared able to select likely functional sites making it difficult to systematically implement such an evolutionary filtering approach.

In effect, we used yeast as an evolutionary "filter" to identify conserved proteins that, through severe functional constraints, have maintained the ability to interact with BRCA1 over a vast evolutionary distance.

(B ) The relative combination of the dynamic filter set and the set from the evolutionary filter to the final hot spots sub-network.

The application of the evolutionary filter revealed that only a small part of the sub-network is made of evolutionary important residues (75 nodes connected by 104 native NCI edges).

In order to contend with these issues and to identify candidate COUP-TFI inner ear and brain target genes, we have employed a methodology that intersects microarray data, in silico genomic analysis with a Hidden Markov Model, and evolutionary conservation filtering.

Specifically, we examined the relationship between recombination rate and other evolutionary correlates after filtering out the effect of GO terms that were overrepresented in each gene constellation.

After adding evolutionary conservation filtering, this percentage reached 14.53%.

Such a "population" approach helps resolve the core actions by filtering the evolutionary noise inherent in short motif recognition systems.

A critical point for filtering by evolutionary conservation is to identify homology.

For example, filtering on evolutionary conservation will miss species-specific or fast evolving miRNAs [ 12] and low-complexity filtering is likely to miss miRNAs originating from transposable elements [ 32, 33].