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Spider silk has been evolutionarily optimized for contextual mechanical performance over the last 400 Ma.
While this architectural configuration is evolutionarily optimized for wind dispersal, such features also lend excellent potential for encapsulating materials, especially in the context of preparing sporopollenin exine capsules (SECs).
The use of artificial pRNA variants, designed to disrupt helix P2 from the 3′-CB instead of the 5′-CB but preventing formation of the CBC helix, indicated that the mechanism of pRNA-induced RNAP release has been evolutionarily optimized for transcriptional pRNA initiation in the 5′-CB.
Hence, surface electrostatic potential of both the SNARE proteins and their regulatory factors appears to have been evolutionarily optimized for this structurally preferred rotation.
Second, the orthogonal tRNACUATyr has not been evolutionarily optimized for UAG decoding, whereas many natural tRNAs are posttranscriptionally modified through evolution for efficient codon recognition.
This article reports a new approach to modeling biological signal transduction systems based on the simple but important assumption that such systems have been evolutionarily optimized for maximum signal transmission efficiency.
Similar(50)
The foldon domain is an evolutionarily optimized trimerization module required for assembly of the large, trimeric structural protein fibritin from phage T4.
The mechanical, rheological and shape properties of red blood cells are determined by their cortical cytoskeleton, evolutionarily optimized to provide the dynamic deformability required for flow through capillaries much narrower than the cell's diameter.
In a highly ordered system such as the well-distanced H-bond chain of an evolutionarily optimized PT pathway, this should at least affect the efficiency of the functional aspect.
Compared with synthetic compounds, natural products are secondary metabolite, evolutionarily optimized with biologically relevant chemical space and preferred ligand binding motif, are not only biologically active, but with a high degree of bioavailability, suitable for functional and phenotypic assays [86].
Evolutionarily optimized cellular infrastructure like ATPases, NCX or IP3R channels might be expected to be robust.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com