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This is consistent with the notion that certain miRNAs have been selected during evolution to regulate TRAIL-induced apoptosis.
In particular, ERF transcripts are among the most interesting TFs because they have been selected through evolution to regulate a series of stress-response pathways.
Moreover, it seems that these modules may have been co-opted during evolution to regulate the decision underlying cell-fate determination of different structures in diverse tissues/organs (e.g. root, hypocotyl and leaf).
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This inspired us to construct a SIM-based adaptive evolution module to regulate the hypermutation state for autonomous adaptive evolution under stresses.
Using examples from both invertebrate and vertebrate systems, this review highlights progress in understanding these basic principles and briefly discusses the possible evolution of strategies to regulate the morphogenesis of tubular systems.
The evolution of a physiological system is necessarily linked to genetic selection pressure [ 38], and the current literature is silent as to what selection pressure would have driven the evolution of systems to regulate physical activity.
The evolution of novel ways to regulate the formation of the cuticle, which is the primary protective barrier and skeletal component, may provide nematodes with greater flexibility when dealing with environmental change and host immune attack.
As sporophytic and gametophytic shoots (gametophores) evolved independently, the convergent shoot morphologies of each generation could have arisen through the recruitment of distinct genetic pathways to regulate development in plant evolution [ 32, 33].
Silica and its induced substances may induce apoptosis to regulate the evolution of silica-induced inflammation and fibrosis.
Furthermore, we are examining the control of macrophage IL-17 expression by factors known to regulate the evolution of Th17 responses including IL-1, IL-6, IL-21 and transforming growth factor beta.
Moreover, if evolution tinkers with Indy expression to regulate important life-history elements in Nature, it suggests that Indy may serve as a natural and important hub for small-molecule intervention linking metabolism, fitness and longevity.
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