Apart from modifications within H3 and H4 type histone, we are currently investigating H2A and H2B [22] modifications and their influence on the model evolution and output parameters.
A Transition element encodes the rules governing the evolution of its Output node depending on the state of its Input nodes, both Input and Output nodes each referencing a particular QualitativeSpecies whilst providing additional information relating to the Transition.
In this note it is shown how for a class of systems for which such a procedure applies, one can further guarantee some constraints on the output evolution, by a special choice of Lyapunov functions in the constructive control design.
The evolution of urine output (P = 0.74), RIFLE classification (P = 0.44) and SOFA score (P = 0.23) was not different.
In contrast, the evolution of scientific output in the field of toxicology has been poorly explored to date and there are few internationally published reports on research activity in toxicology [ 11- 16].
To test the network, we measured the time evolution of all output units, over 80 time steps, after presenting a morphed pattern (or the original images from which the patterns were morphed) in the input layer.
We also noted the evolution of urine output, the risk of renal dysfunction, injury to the kidney, failure of kidney function, loss of kidney function and end-stage kidney disease (RIFLE) classification and sepsis related organ failure assessment (SOFA) score over 3 weeks.
However, in what concerns the evolution of the output protein Z, a detailed analysis of this system (see additional file 1) shows that two cases should be distinguished according to the size of the pulse duration τ compared with the proper pulse τ θ of the IFFL [cf. eq. (6)].
